The role of sclerostin/dickkopf-1 and receptor activator of nuclear factor kB ligand/osteoprotegerin signalling pathways in the development of osteoporosis in patients with haemophilia A and B: A cross-sectional study.
Panagiotis AnagnostisS VakalopoulouD ChristoulasS A PaschouA PapatheodorouV GaripidouP KokkorisE TerposPublished in: Haemophilia : the official journal of the World Federation of Hemophilia (2017)
Patients with haemophilia present increased osteoclastic activity coupled with compensatory increased osteoblastic activity. Ibandronate did not affect RANKL/OPG ratio, but it decreased Dkk-1.