Estimating HLA haplotype frequencies from homozygous individuals - A Technical Report.

Susanne SeitzVinzenz LangePaul J NormanJürgen Sauter Alexander H Schmidt

Published in: International journal of immunogenetics (2021)

We estimated HLA haplotype frequencies based on individuals homozygous for 4, 5 or 6 loci. Validation of our approach using a sample of over 3.4 million German individuals was successful. Compared to an expectation-maximization algorithm, the errors were larger. However, our approach allows the unequivocal detection of rare haplotypes.

Keyphrases

machine learning
genome wide
deep learning
patient safety
gene expression
dna methylation
quality improvement