Epithelial-mesenchymal transition induction is associated with augmented glucose uptake and lactate production in pancreatic ductal adenocarcinoma.

Menghan LiuLake-Ee QuekGhazal SultaniNigel Turner

Published in: Cancer & metabolism (2016)

Our results characterize the metabolic reprogramming occurring during PDAC cell EMT and highlight the common changes of increased glucose uptake and lactate secretion under different EMT conditions. Such insight is urgently required for designing metabolic strategies to selectively target cells undergoing EMT in PDAC.

Keyphrases

epithelial mesenchymal transition
transforming growth factor
signaling pathway
induced apoptosis
blood glucose
cell cycle arrest
single cell
cell therapy
type diabetes
cell death
endoplasmic reticulum stress
cell proliferation
insulin resistance