Retinal Optical Coherence Tomography in Neuromyelitis Optica.
Frederike Cosima OertelSvenja SpecoviusHanna G ZimmermannClaudia ChienSeyedamirhosein MotamediCharlotte BereuterLawrence CookMarco Aurélio Lana PeixotoMariana Andrade FontanelleHo Jin KimJae-Won HyunJacqueline PalaceAdriana Roca-FernandezMaria Isabel LeiteSrilakshmi SharmaFereshteh AshtariRahele KafiehAlireza DehghaniMohsen PouraziziLekha PanditAnitha D'CunhaOrhan AktasMarius RingelsteinPhilipp AlbrechtEugene MayCaryl TongcoLetizia LeocaniMarco PisaMarta RadaelliElena Hernandez Martinez-LapiscinaHadas Stiebel-KalishSasitorn SirithoJérome de SezeThomas SengerJoachim HavlaRomain MarignierAlvaro Cobo CalvoDenis BichuettiIvan Maynart TavaresNasrin AsgariKerstin SoelbergAyse AltintasRengin YildirimUygur TanriverdiAnu JacobSaif HudaZoe RimlerAllyson ReidYang Mao-DraayerIbis Soto de CastilloAxel PetzoldAri J GreenMichael R YeamanTerry SmithAlexander Ulrich BrandtFriedemann PaulPublished in: Neurology(R) neuroimmunology & neuroinflammation (2021)
Our results emphasize that attack prevention is key to avoid severe neuroaxonal damage and vision loss caused by ON in NMOSD. Therapies ameliorating attack-related damage, especially during a first attack, are an unmet clinical need. Mild signs of neuroaxonal changes without apparent vision loss in ON-unaffected eyes might be solely due to contralateral ON attacks and do not suggest clinically relevant progression but need further investigation.