Slit2/Robo4 axis may contribute to endothelial cell dysfunction and angiogenesis disturbance in systemic sclerosis.
Eloisa RomanoMirko ManettiIrene RosaBianca Saveria FiorettoLidia Ibba-ManneschiMarco Matucci-CerinicSerena GuiducciPublished in: Annals of the rheumatic diseases (2018)
In SSc, increased circulating levels of Slit2 and activation of the Slit2/Robo4 antiangiogenic axis may contribute to peripheral microangiopathy since the very early phase of the disease.