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Refinement of an Established Procedure and Its Application for Identification of Hypoxia in Prostate Cancer Xenografts.

Pernille B ElmingThomas R WittenbornMorten BuskBrita Singers SørensenMathilde Borg Houlberg ThomsenTrine StrandgaardLars DyrskjøtSteffen NielsenMichael R Horsman
Published in: Cancers (2021)
We have developed a combined autoradiographic/laser-guided microdissection method with broad applicability. Using this approach on fresh frozen tumor material, thereby minimizing the degree of RNA degradation, we showed that the 15-gene hypoxia gene classifier developed in HNSCC may be applicable for adenocarcinomas such as prostate cancer.
Keyphrases
  • prostate cancer
  • radical prostatectomy
  • copy number
  • genome wide
  • endothelial cells
  • genome wide identification
  • minimally invasive
  • genome wide analysis
  • dna methylation
  • high resolution
  • bioinformatics analysis