Mediation analysis of the testosterone treatment effect to prevent type 2 diabetes in the T4DM trial.

Kristy P RobledoIan C MarschnerDavid J HandelsmanKaren BrackenBronwyn G A StuckeyBu B YeapWarrick InderMathis GrossmannDavid JesudasonCarolyn A AllanGary Wittert

Published in: European journal of endocrinology (2023)

At least part of the testosterone treatment effect was found to be mediated by changes in fat mass, abdominal fat, skeletal muscle mass, grip strength, SHBG, and E2, but predominantly by changes in fat mass.

Keyphrases

type diabetes
skeletal muscle
adipose tissue
replacement therapy
insulin resistance
clinical trial
cardiovascular disease
metabolic syndrome
glycemic control
combination therapy
study protocol
phase iii
weight loss
phase ii