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4-(N)-Docosahexaenoyl 2', 2'-difluorodeoxycytidine induces immunogenic cell death in colon and pancreatic carcinoma models as a single agent.

Stephanie HufnagelHaiyue XuMichael F ColemamSolange A ValdesKristyn A LiuStephen D HurstingZhengrong Cui
Published in: Cancer chemotherapy and pharmacology (2021)
DHA-dFdC is a bona fide ICD inducer and can render pancreatic tumors responsive to anti-PD-1 mAb therapy.
Keyphrases
  • cell death
  • cancer therapy
  • cell cycle arrest
  • stem cells
  • monoclonal antibody
  • signaling pathway
  • replacement therapy