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CCT245718, a dual FLT3/Aurora A inhibitor overcomes D835Y-mediated resistance to FLT3 inhibitors in acute myeloid leukaemia cells.

Muhammad Usama TariqMuhammad FurqanHira ParveenRahim UllahMuhammad MuddassarRahman Shah Zaib SaleemVassilios BavetsiasSpiros LinardopoulosAmir Faisal
Published in: British journal of cancer (2021)
Our results demonstrate that CCT245718 is a potent dual FLT3/Aurora A inhibitor that can overcome TKD-mediated acquired resistance.
Keyphrases
  • acute myeloid leukemia
  • tyrosine kinase
  • induced apoptosis
  • liver failure
  • respiratory failure
  • drug induced
  • oxidative stress
  • signaling pathway
  • hepatitis b virus
  • intensive care unit