A Bi-Exponential Repair Algorithm for Radiation-Induced Double-Strand Breaks: Application to Simulation of Chromosome Aberrations.
Ianik PlanteTony SlabaZarana ShaversMegumi HadaPublished in: Genes (2019)
The main findings are: i) the curves for the kinetics of restitution of DSBs are mostly independent of dose; ii) the fraction of unrepaired breaks increases with the linear energy transfer (LET) of the incident radiation; iii) the simulated dose-response curves for simple reciprocal chromosome exchanges that are linear-quadratic; iv) the alpha coefficient of the dose-response curve peaks at about 100 keV/µm.
Keyphrases
- radiation induced
- energy transfer
- copy number
- radiation therapy
- quantum dots
- machine learning
- neural network
- cardiovascular disease
- deep learning
- genome wide
- diffusion weighted imaging
- dna methylation
- magnetic resonance imaging
- gene expression
- type diabetes
- magnetic resonance
- virtual reality
- dual energy
- contrast enhanced