No association between IFNL3 (IL28B) genotype and response to peginterferon alfa-2a in HBeAg-positive or -negative chronic hepatitis B.

Lai WeiHeiner WedemeyerYun-Fan LiawHenry Lik-Yuen ChanTeerha PiratvisuthPatrick MarcellinJidong JiaDeming TanWan-Cheng ChowMaurizia R BrunettoMoisés DiagoSelim GurelViacheslav MorozovHua HeYonghong ZhuCynthia WatBernadette SurujballyAlexander James Thompson

Published in: PloS one (2018)

This is the largest analysis to date of associations between IFNL3 genotype and peginterferon response in patients with chronic hepatitis B. The data suggest that IFNL3 polymorphism is not a major determinant of the response to peginterferon alfa-2a in either HBeAg-positive or HBeAg-negative patients.

Keyphrases

hepatitis b virus
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
peritoneal dialysis
replacement therapy
electronic health record
big data
patient reported outcomes
deep learning