Epigenome-wide association study on diffusing capacity of the lung.

Natalie TerzikhanHanfei XuAhmed EdrisKen R BrackeFien M VerhammeBruno H C StrickerJosée DupuisLies LahousseGeorge T O'ConnorGuy G O Brusselle

Published in: ERJ open research (2021)

We report on epigenome-wide associations with diffusing capacity in the general population. Our results suggest EXOC3 to be an excellent candidate, through which smoking-induced hypomethylation of AHRR might affect pulmonary gas exchange.

Keyphrases

dna methylation
pulmonary hypertension
high glucose
diabetic rats
gene expression
oxidative stress
endothelial cells
carbon dioxide