Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021.
Takahito OuchiYoshihiro WatanabeKenichi NonakaReiko MuramatsuChikako NoguchiMiho TozawaRei HokariAki IshiyamaRima KoikeHidehito MatsuiYukihiro AsamiYuki InahashiTakahiro IshiiToshiaki TeruyaMasato IwatsukiHideaki HanakiSatoshi ŌmuraPublished in: The Journal of antibiotics (2020)
Three new antimalarial compounds, clonocoprogens A, B, and C, were isolated from the static culture of an Okinawan fungus, Clonostachys compactiuscula FKR-0021. These compounds were new analogs of N14-palmitoylcoprogen, reported as a siderophore. They showed moderate antimalarial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains, with IC50 values ranging from 1.7 to 9.9 µM.