Potential of fluorescent nanoprobe in diagnosis and treatment of Alzheimer's disease.
Jingjing LinHanhan LiJingxuan GuoYue XuHua LiJun YanYuxin WangHaiyan ChenZhenwei YuanPublished in: Nanomedicine (London, England) (2022)
Alzheimer's disease (AD) is well known for its insidious nature, slow progression and high incidence as a neurodegenerative disease. In the past, diagnosis of AD mainly depended on analysis of a patient's cognitive ability and behavior. Without a unified standard for analysis methods, this is prone to produce incorrect diagnoses. Currently, definitive diagnosis mainly relies on histopathological examination. Because of the advantages of precision, noninvasiveness, low toxicity and high spatiotemporal resolution, fluorescent nanoprobes are suitable for the early diagnosis of AD. This review summarizes the research progress of different kinds of fluorescent nanoprobes for AD diagnosis and therapy in recent years and provides an outlook on the development prospects of fluorescent nanoprobes.
Keyphrases
- living cells
- quantum dots
- fluorescence imaging
- cognitive decline
- label free
- fluorescent probe
- risk factors
- oxidative stress
- stem cells
- case report
- radiation therapy
- photodynamic therapy
- mesenchymal stem cells
- bone marrow
- human health
- mild cognitive impairment
- locally advanced
- current status
- smoking cessation
- replacement therapy