Randomized parallel control trial checking the efficacy and impact of two concentrations of retinol in the original formula on the aging skin condition: Pilot study.

The topical formulation of liquid crystal serum with retinol 0.15% and 0.3% improves the overall skin condition after 8 weeks. Burning, pruritus, dryness, and erythema caused by the application of retinol 0.15% and 0.3% concentrations were minimal. Nevertheless, there were no significance changes found between the left and right side of the face. These encouraging results justify a longer-term study to determine whether topically applied retinol 0.3% can provide more benefits as compared to those observed after topical application of retinol 0.15%.