Control of Spontaneous HPV16 E6/E7 Expressing Oral Cancer in HLA-A2 (AAD) Transgenic Mice with Therapeutic HPV DNA Vaccine.

Ssu-Hsueh TsengLi LiuShiwen PengJinhwi KimLouise FerrallChien-Fu HungT -C Wu

Published in: Journal of biomedical science (2021)

Taken together, the data indicated that the combination of HPV16 E6/E7-expressing DNA, NRasG12V DNA and DNA encoding sleeping beauty transposase is able to generate spontaneous oral tumor in HLA-A2 (AAD) transgenic mice, which can be successfully controlled by treatment with CRT/E7(N53S) DNA vaccine. The translational potential of our studies are discussed.

Keyphrases

circulating tumor
cell free
single molecule
high grade
nucleic acid
circulating tumor cells
electronic health record
risk assessment
heart failure
machine learning
deep learning
case control