Convergent effects of a functional C3 variant on brain atrophy, demyelination, and cognitive impairment in multiple sclerosis.

Tina RoostaeiShokufeh SadaghianiRahil MashhadiMasih FalahatianEsmaeil MohamadiNina JavadianAria NazeriRozita DoostiAbdorreza Naser MoghadasiMahsa OwjiAmir Pejman Hashemi TaheriAli Shakouri RadAmirreza AzimiAristotle N VoineskosArash NazeriMohammad Ali Sahraian

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2018)

C3-rs2230199 affects white and GM damage as well as cognitive impairment in MS patients. Our findings support a causal role for complement system activity in the pathophysiology of MS.

Keyphrases

multiple sclerosis
cognitive impairment
mass spectrometry
end stage renal disease
white matter
ms ms
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
oxidative stress
blood brain barrier
brain injury