Palladium-Catalyzed Pyrazole-Directed sp3 C-H Bond Arylation for the Synthesis of β-Phenethylamines.

Published in: Angewandte Chemie (International ed. in English) (2017)

We have developed a method for palladium-catalyzed, pyrazole-directed sp3 C-H bond arylation by aryl iodides. The reaction employs a Pd(OAc)2 catalyst at 5-10 mol % loading and silver(I) oxide as a halide-removal agent, and it proceeds in acetic acid or acetic acid/hexafluoroisopropanol solvent. Ozonolysis of the pyrazole moiety affords pharmaceutically important β-phenethylamines.

Keyphrases

molecular docking
ionic liquid
gold nanoparticles
room temperature
molecular dynamics simulations
solar cells
highly efficient
electron transfer
metal organic framework