Landscape of gut mucosal immune cells showed gap of follicular or memory B cells into plasma cells in immunological non-responders.

Zerui WangCheng ZhenXiaoyan GuoMengmeng QuChao ZhangJinwen SongXing FanHuihuang HuangRuonan XuJiyuan ZhangJinhong YuanWeiguo HongJiaying LiFu-Sheng WangYan-Mei JiaoEnqiang Linghu

Published in: Clinical and translational medicine (2024)

An investigation was carried out at the single-cell-level to analyze gut mucosal immune cells alterations in PLWH after ART. B cells were significantly increased and plasma cells were significantly decreased in the INRs compared to the IRs and NCs. There are gaps in the transition from gut follicular or memory B cellsinto plasma cells in INRs.

Keyphrases

induced apoptosis
cell cycle arrest
single cell
endoplasmic reticulum stress
working memory
cell death
oxidative stress
high throughput
ulcerative colitis