Step-by-Step Design of New Theranostic Nanoformulations: Multifunctional Nanovectors for Radio-Chemo-Hyperthermic Therapy under Physical Targeting.
Shoeb Anwar AnsariEleonora FiciaràFederico D'AgataRoberta CavalliLucia NasiFrancesca CasoliFranca AlbertiniCaterina GuiotPublished in: Molecules (Basel, Switzerland) (2021)
While investigating the possible synergistic effect of the conventional anticancer therapies, which, taken individually, are often ineffective against critical tumors, such as central nervous system (CNS) ones, the design of a theranostic nanovector able to carry and deliver chemotherapy drugs and magnetic hyperthermic agents to the target radiosensitizers (oxygen) was pursued. Alongside the original formulation of polymeric biodegradable oxygen-loaded nanostructures, their properties were fine-tuned to optimize their ability to conjugate therapeutic doses of drugs (doxorubicin) or antitumoral natural substances (curcumin). Oxygen-loaded nanostructures (diameter = 251 ± 13 nm, ζ potential = -29 ± 5 mV) were finally decorated with superparamagnetic iron oxide nanoparticles (SPIONs, diameter = 18 ± 3 nm, ζ potential = 14 ± 4 mV), producing stable, effective and non-agglomerating magnetic nanovectors (diameter = 279 ± 17 nm, ζ potential = -18 ± 7 mV), which could potentially target the tumoral tissues under magnetic driving and are monitorable either by US or MRI imaging.
Keyphrases
- cancer therapy
- drug delivery
- photodynamic therapy
- iron oxide nanoparticles
- fluorescence imaging
- drug release
- molecularly imprinted
- optic nerve
- physical activity
- magnetic resonance imaging
- human health
- iron oxide
- magnetic resonance
- locally advanced
- radiation therapy
- blood brain barrier
- stem cells
- bone marrow
- squamous cell carcinoma
- climate change
- cell therapy
- mesenchymal stem cells