Effect of levodopa on postural blood pressure changes in Parkinson disease: a randomized crossover study.
Timi EarlAmani JridiPerla C ThulinMeghan ZornKathleen E McKeeKristin MitrovichPaolo MorettiJumana AlshaikhPanagiotis KassavetisMelissa M CortezGuillaume LamottePublished in: Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2024)
Levodopa decreases blood pressure in both PD with and without autonomic failure, but it does not cause a greater fall in blood pressure from supine to standing at 3 min. Levodopa-induced baroreflex sympathetic noradrenergic impairment may contribute to lower blood pressure. Lower standing blood pressure with levodopa may increase the risks of fall and syncope.