Metformin promotes susceptibility to experimental Leishmania braziliensis infection.

Filipe Rocha LimaLais de Melo FerreiraTainá Alves MaltaIcaro Bonyek-SilvaReinan Lima SantosNatália Machado TavaresEdgar Marcelino de Carvalho FilhoSérgio Arruda

Published in: Memorias do Instituto Oswaldo Cruz (2020)

Experimental treatment with MET interfered with the kinetics of cutaneous ulceration, increased Lb parasite load, altered ROS production and modulated cellular proliferation. Our experimental results indicate that MET interfere with the evolution of CL.

Keyphrases

tyrosine kinase
dna damage
signaling pathway
combination therapy