Preparation of enantioenriched helical- and axial-chiral molecules by dynamic asymmetric induction.

Yuuya KawasakiRyota KamikuboYuta KumegawaKouhei OgawaTakeru KashiwagiYusuke Ano Kazunobu Igawa Katsuhiko Tomooka

Published in: Chemical communications (Cambridge, England) (2022)

Dynamic asymmetric induction (DYASIN) of racemic dynamic chiral heterohelicenes afforded their highly enantioenriched forms (up to 96% ep) in quantitative yields. These heterohelicenes were readily converted into semi-static axial-chiral 1,1'-binaphthyl derivatives in a stereospecific manner.

Keyphrases

capillary electrophoresis
ionic liquid
high resolution
mass spectrometry
solid state
tandem mass spectrometry