Brain Damage and Gene Expression Across Hereditary Spastic Paraplegia Subtypes.

Katiane R ServelhereThiago Junqueira Ribeiro RezendeFabricio Diniz de LimaMariana Rabelo de BritoRenan Flávio de França NunesRaphael F CassebJosé Luiz PedrosoOrlando Graziani P BarsottiniFernando CendesMarcondes C França

Published in: Movement disorders : official journal of the Movement Disorder Society (2021)

Brain damage is a conspicuous feature of HSPs (even for pure subtypes), but the pattern of abnormalities is genotype-specific. Correlation between brain structural damage and gene expression maps is different for autosomal dominant and recessive HSPs, pointing to distinct pathophysiological mechanisms underlying brain damage in these subgroups of the disease. © 2021 International Parkinson and Movement Disorder Society.

Keyphrases

gene expression
resting state
white matter
oxidative stress
functional connectivity
dna methylation
cerebral ischemia
machine learning
deep learning
intellectual disability
brain injury
cerebral palsy
heat stress