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NUIG4: A biocompatible pcu metal-organic framework with an exceptional doxorubicin encapsulation capacity.

Ahmed AhmedConstantinos G EfthymiouRana SaniiEwa Patyk-KaźmierczakAmir M AlsharabasyMeghan WinterlichNaveen KumarDebobroto SensharmaWenming TongSarah GuerinPau FarràsSarah P HudsonDamien ThompsonMichael J ZaworotkoAnastasios J TasiopoulosConstantina Papatriantafyllopoulou
Published in: Journal of materials chemistry. B (2022)
Metal-organic frameworks (MOFs) are promising multifunctional porous materials for biomedical and environmental applications. Here, we report synthesis and characterization of a new MOF based on the tetrahedral secondary building unit [Zn 4 O(CBAB) 3 ] n (NUIG4), where CBABH 2 = 4-((4-carboxybenzylidene)amino)benzoic acid. NUIG4 belongs to the family of MOFs with primitive cubic pcu topology, being a rare example with 4-fold interpenetration. The pore architecture enables unprecedentedly high doxorubicin (DOX) loading capacity (1955 mg DOX/g NUIG4) with pH-controlled release. Solid-state NMR and ab initio modeling confirmed formation of aromatic π-π stacking interactions between DOX and the framework. Preliminary cell-line experiments suggested a protective effect of NUIG4 on healthy HDF cells against DOX toxicity. NUIG4 also displays potential for adsorptive small-molecule gas separation, with a BET surface area of 1358 m 2 g -1 and high selectivity of 2.75 for C 2 H 2 over CO 2 .
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