NUIG4: A biocompatible pcu metal-organic framework with an exceptional doxorubicin encapsulation capacity.
Ahmed AhmedConstantinos G EfthymiouRana SaniiEwa Patyk-KaźmierczakAmir M AlsharabasyMeghan WinterlichNaveen KumarDebobroto SensharmaWenming TongSarah GuerinPau FarràsSarah P HudsonDamien ThompsonMichael J ZaworotkoAnastasios J TasiopoulosConstantina PapatriantafyllopoulouPublished in: Journal of materials chemistry. B (2022)
Metal-organic frameworks (MOFs) are promising multifunctional porous materials for biomedical and environmental applications. Here, we report synthesis and characterization of a new MOF based on the tetrahedral secondary building unit [Zn 4 O(CBAB) 3 ] n (NUIG4), where CBABH 2 = 4-((4-carboxybenzylidene)amino)benzoic acid. NUIG4 belongs to the family of MOFs with primitive cubic pcu topology, being a rare example with 4-fold interpenetration. The pore architecture enables unprecedentedly high doxorubicin (DOX) loading capacity (1955 mg DOX/g NUIG4) with pH-controlled release. Solid-state NMR and ab initio modeling confirmed formation of aromatic π-π stacking interactions between DOX and the framework. Preliminary cell-line experiments suggested a protective effect of NUIG4 on healthy HDF cells against DOX toxicity. NUIG4 also displays potential for adsorptive small-molecule gas separation, with a BET surface area of 1358 m 2 g -1 and high selectivity of 2.75 for C 2 H 2 over CO 2 .
Keyphrases
- metal organic framework
- solid state
- small molecule
- drug delivery
- induced apoptosis
- cancer therapy
- magnetic resonance
- human health
- cell cycle arrest
- high resolution
- room temperature
- heavy metals
- ionic liquid
- protein protein
- drug release
- signaling pathway
- endoplasmic reticulum stress
- climate change
- liquid chromatography
- cell death
- highly efficient