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Neuroprotection in early stages of Alzheimer's disease is promoted by transthyretin angiogenic properties.

Tiago GiãoJoana SaavedraJosé Ricardo VieiraMarta Teixeira PintoGemma ArsequellIsabel Cardoso
Published in: Alzheimer's research & therapy (2021)
Our in vivo results demonstrate the involvement of TTR in angiogenesis, particularly as a modulator of vascular alterations occurring in AD. Since TTR is decreased early in AD, its tetrameric stabilization can represent a therapeutic avenue for the early treatment of AD through the maintenance of the vascular structure.
Keyphrases
  • endothelial cells
  • brain injury
  • vascular endothelial growth factor
  • cerebral ischemia