The relationship of airway structural changes to blood and bronchoalveolar lavage biomarkers, and lung function abnormalities in asthma.

Pawel KozlikJoanna ZukSylwia BartyzelJacek ZarychtaKrzysztof OkonLech ZarebaJan G BazanJoanna KosalkaJerzy SojaJacek MusialStanisława Bazan-Socha

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2019)

Airway remodelling traits are mainly related to the Th2 profile, higher circulating ADAM33, and blood neutrophilia. Lung function abnormalities and RBM thickening correlate better with CT-metrics of distal than proximal airways.

Keyphrases

lung function
cystic fibrosis
chronic obstructive pulmonary disease
air pollution
computed tomography
minimally invasive
genome wide
image quality
magnetic resonance imaging
dual energy
dna methylation
gene expression
drug induced