Ni-Al Bimetallic Catalyzed Enantioselective Cycloaddition of Cyclopropyl Carboxamide with Alkyne.
Qi-Sheng LiuDe-Yin WangZhi-Jun YangYu-Xin LuanJin-Fei YangJiang-Fei LiYou-Ge PuMengchun YePublished in: Journal of the American Chemical Society (2017)
A Ni-Al bimetallic catalyzed enantioselective cycloaddition reaction of cyclopropyl carboxamides with alkynes has been developed. A series of cyclopentenyl carboxamides were obtained in up to 99% yield and 94% ee. The bifunctional-ligand-enabled bimetallic catalysis proved to be an efficient strategy for the C-C bond cleavage of unreactive cyclopropanes.