Restoration of MARCKS enhances chemosensitivity in cancer.

Tim WenzelThomas BüchNicole UrbanUlrike WeirauchKatrin SchierleAchim AignerMichael SchaeferHermann Kalwa

Published in: Journal of cancer research and clinical oncology (2020)

Cells devoid of MARCKS function showed incomplete ABCB1 internalization, leading to higher ABCB1 activity enhancing chemoresistance. Vice versa our data suggest the prevention of MARCKS inhibition by reversing hyperphosphorylation or genomic restoration after deletion as two promising approaches to overcome tumor cell resistance towards chemotherapeutic ABCB1 substrates.

Keyphrases

single cell
cell therapy
electronic health record
big data
stem cells
gene expression
mesenchymal stem cells
artificial intelligence