17R/S-Benzo-RvD1, a synthetic resolvin D1 analogue, attenuates neointimal hyperplasia in a rat model of acute vascular injury.

Alexander S KimEvan C WerlinHideo KagayaMian ChenBian WuGiorgio MottolaMasood JanMichael S Conte

Published in: PloS one (2022)

17R/S-benzo-RvD1 and 17R-RvD1 exhibit similar pro-resolving and anti-migratory activity in cell-based assays, and both compounds attenuated NIH following acute arterial injury in rats. Further studies of the mechanisms of resolution following vascular injury, and the translational potential of SPM analogues, are indicated.

Keyphrases

liver failure
respiratory failure
drug induced
aortic dissection
single cell
cell therapy
hepatitis b virus
stem cells
vascular smooth muscle cells
single molecule
intensive care unit
climate change
angiotensin ii