Cathepsin K deficiency promotes alveolar bone regeneration by promoting jaw bone marrow mesenchymal stem cells proliferation and differentiation via glycolysis pathway.
Wuyang ZhangZhiwei DongDengke LiBei LiYuan LiuXueni ZhengHui LiuHongzhi ZhouKaijin HuYang XuePublished in: Cell proliferation (2021)
Our findings revealed that Ctsk knockout or inhibition could promote alveolar bone regeneration by enhancing JBMMSC regeneration via glycolysis. These results shed new lights on the regulatory mechanism of CTSK on bone regeneration.