Kynurenic Acid: A Novel Player in Cardioprotection against Myocardial Ischemia/Reperfusion Injuries.

Rima KamelDelphine BaetzNaïg GueguenLucie LebeauAgnès BarbelivienAnne-Laure GuihotLouwana AllawaJean GalletJustine BeaumontMichel OvizeDaniel Henrion Pascal ReynierDelphine Mirebeau-PrunierFabrice PrunierSophie Tamareille

Published in: Pharmaceuticals (Basel, Switzerland) (2023)

Here we show that KYNA-mediated cardioprotection was associated with enhanced mitophagy and antioxidant defense. A deeper understanding of KYNA's cardioprotective mechanisms is necessary to identify promising novel therapeutic targets and their translation into the clinical arena.

Keyphrases

oxidative stress
left ventricular
anti inflammatory
innate immune
atrial fibrillation