Intensive insulin therapy increases glutathione synthesis rate in surgical ICU patients with stress hyperglycemia.
Gianni BioloBenedetta MassolinoFilippo Giorgio Di GirolamoNicola FiottiFilippo MearelliSara MazzuccoCarlos BertuzziRenzo LazzariniAlfonso ColombattiMarcello De CiccoPublished in: PloS one (2018)
In patients developing stress hyperglycemia after major surgery, IIT, in absence of hypoglycemia, stimulates erythrocyte glutathione synthesis, while decreasing oxidative stress.
Keyphrases
- oxidative stress
- type diabetes
- end stage renal disease
- newly diagnosed
- diabetic rats
- ejection fraction
- chronic kidney disease
- intensive care unit
- prognostic factors
- dna damage
- peritoneal dialysis
- glycemic control
- coronary artery bypass
- patient reported outcomes
- ischemia reperfusion injury
- metabolic syndrome
- coronary artery disease
- signaling pathway
- adipose tissue
- atrial fibrillation