Mucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma.

Jaime A EspinozaIsmael RiquelmeEduardo A SagredoLorena RosaPatricia GarcíaCarolina BizamaMaría Apud-BellPamela LealHelga WeberFelipe BenaventeSergio VargasDiego RomeroAlexis M KalergisJuan Carlos Roa

Published in: Histopathology (2019)

CLDN18 is a new metaplasia marker in gallbladder tissues, and is conserved in approximately half of GBC cases. MUC5B and CA9 are highly conserved during GBC histological progression. The three markers are potential theranostic markers, in particular CA9 and CLDN18, for which there are already targeted therapies available.

Keyphrases

photodynamic therapy
gene expression
fluorescence imaging
human health
protein kinase