Non-mercaptalbumin, Oxidized Form of Serum Albumin, Significantly Associated with Renal Function and Anemia in Chronic Kidney Disease Patients.
Shinya NakataniKeiko YasukawaEiji IshimuraAyumi NakataniNorikazu ToiHideki UedonoAkihiro TsudaShinsuke YamadaHitoshi IkedaKatsuhito MoriMasanori EmotoYutaka YatomiMasaaki InabaPublished in: Scientific reports (2018)
Oxidative stress plays a major role in development of cardiovascular disease in patients with chronic kidney disease (CKD). Human mercaptalbumin (HMA), a reduced form of serum albumin, and non-mercaptalbumin (HNA), an oxidized form of serum albumin, are known as indicators for evaluating oxidative stress in systemic circulation, including end-stage renal disease cases. We investigated factors associated with fraction of HNA [f(HNA)] in 112 pre-dialysis CKD patients (63.6 ± 14.0 years old; 59 males, 53 females) using a newly established anion-exchange column packed with hydrophilic polyvinyl alcohol gel as well as high performance liquid chromatography. Mean f(HNA) in our CKD patients was 30.0 ± 6.1%, higher than that previously reported for healthy subjects. In multiple regression analysis, age (β = 0.200, p = 0.014), eGFR (β = -0.238, p = 0.009), hemoglobin (β = -0.346, p < 0.001), and ferritin (β = 0.200, p = 0.019) were significantly and independently associated with f(HNA) (R2 = 0.356, p < 0.001). In addition, factors related to CKD-mineral and bone disorder (CKD-MBD), including intact-PTH (β = 0.218, p = 0.049) and 1,25-dihydroxyvitamin D (1,25(OH)2D) (β = -0.178, p = 0.040), were significantly and independently associated with serum f(HNA) (R2 = 0.339, p < 0.001), whereas fibroblast growth factor-23 was not. These findings indicate the importance of management of hemoglobin and ferritin levels, as well as appropriate control of CKD-MBD factors for a better redox state of serum albumin in CKD patients.
Keyphrases
- end stage renal disease
- chronic kidney disease
- peritoneal dialysis
- cardiovascular disease
- oxidative stress
- ejection fraction
- small cell lung cancer
- high performance liquid chromatography
- endothelial cells
- mass spectrometry
- coronary artery disease
- endoplasmic reticulum stress
- induced pluripotent stem cells
- tyrosine kinase
- soft tissue
- high speed
- bone mineral density