Impact of natriuretic peptide polymorphisms on diastolic and metabolic function in a populational cohort: insights from the STANISLAS cohort.

Constance XhaardRaphaël RougetNicolas VodovarEdith Le FlochClaire Dandine-RoullandSandra WagnerDelphine Bacq-DaianQuentin ThuillierJean-Marc BoivinChristiane BranlantJean-François DeleuzeIsabelle Behm-AnsmantFaiez ZannadPatrick RossignolNicolas Girerd

Published in: ESC heart failure (2021)

The heritability of natriuretic peptides appears relatively low (15%) and mainly based on the same gene cluster constituted of MTHFR, CLCN6, NPPA, NPPB, and C1orf167. Natriuretic peptide polymorphisms are associated with natriuretic peptide levels and diastolic function. These results suggest that natriuretic peptide polymorphisms may have an impact in the early stages of cardiovascular and metabolic disease.

Keyphrases

left ventricular
blood pressure
ejection fraction
genome wide
dna methylation
gene expression
genome wide identification