Eye movement alterations in presymptomatic C9orf72 expansion gene carriers.
Anna BehlerAntje KnehrJulia FinselMartin S KunzChristina LangKathrin MüllerHans-Peter MüllerElmar H PinkhardtAlbert C LudolphDorothée LuléJan KassubekPublished in: Journal of neurology (2021)
In C9orf72 carriers, executive eye movement dysfunctions, especially the increased anti-saccade error rate, were associated with cognitive impairment and unrelated to time. These oculomotor impairments are in support of developmental deficits in these mutations, especially in prefrontal areas.