High-Dose Methotrexate in Patients With Lymphoma: Predictors of a Complicated Course.
Darragh F O'DonoghueHuong L TruongHeidi D FinnesJennifer S McDonaldHeather Personett MayStephen M AnsellN Nora BennaniThomas M HabermannDavid J InwardsPatrick B JohnstonArushi KhuranaYi LinIvana N MicallefGrzegorz S NowakowskiJonas PaludoLuis F PorrataGita ThanarajasingamCarrie A ThompsonJose C Villasboas BisnetoYucai WangThomas E WitzigNelson R LeungPublished in: JCO oncology practice (2022)
Elevated MTX levels are associated with a significant increased rate of AKI, ICU admission, prolonged LOS, and 30-day mortality. Elevated 48-hour MTX levels, particularly > 1.28 μmol/L, should alert clinicians for complications and to initiate measures to reduce MTX levels.