A new triterpenoid saponin ( 1 ), along with five known compounds ( 2-6 ), was isolated from Bupleurum marginatum Wall. ex DC, of which compounds 2-4 were obtained for the first time from this plant. The structures were confirmed by the analysis of 1D, 2D NMR, and HR-ESIMS data, and comparison with previous spectral data. Anti-liver fibrotic activities of the isolates were determined as proliferation inhibition of LPS-induced activation of HSC-T6 in vitro .
Keyphrases
- lps induced
- inflammatory response
- electronic health record
- high resolution
- systemic sclerosis
- idiopathic pulmonary fibrosis
- big data
- magnetic resonance
- signaling pathway
- optical coherence tomography
- dendritic cells
- computed tomography
- machine learning
- immune response
- magnetic resonance imaging
- solid state
- artificial intelligence
- deep learning