Ruscogenin attenuates sepsis-induced acute lung injury and pulmonary endothelial barrier dysfunction via TLR4/Src/p120-catenin/VE-cadherin signalling pathway.
Yuwei WangLixuan XueYunhao WuJiazhi ZhangYujie DaiFang LiJunping KouYuanyuan ZhangPublished in: The Journal of pharmacy and pharmacology (2021)
RUS attenuated sepsis-induced ALI via protecting pulmonary endothelial barrier and regulating TLR4/Src/p120-catenin/VE-cadherin signalling pathway.
Keyphrases
- high glucose
- endothelial cells
- pulmonary hypertension
- toll like receptor
- inflammatory response
- diabetic rats
- intensive care unit
- epithelial mesenchymal transition
- tyrosine kinase
- cell proliferation
- immune response
- septic shock
- lipopolysaccharide induced
- oxidative stress
- drug induced
- lps induced
- cell migration
- nuclear factor
- cell adhesion
- signaling pathway