H3K27me3 loss indicates an increased risk of recurrence in the Tübingen meningioma cohort.

Felix BehlingChristina FodiIrina Gepfner-TumaKristina KaltenbachMirjam RenovanzFrank PaulsenMarco SkardellyJürgen HoneggerMarcos Tatagibanull nullCornelia Brendle Ghazaleh Tabatabai

Published in: Neuro-oncology (2021)

Loss of H3K27me3 combined with MIB1 labeling index are independent prognostic factors in meningioma. These data from the Tübingen meningioma cohort support the clinical utility of H3K27me3 immunohistochemical staining in meningioma and its integration into the routine histopathological workup.

Keyphrases

prognostic factors
optic nerve
clinical practice
electronic health record
machine learning
optical coherence tomography
deep learning
flow cytometry