Oxygen supplementation in anesthesia can block FLASH effect and anti-tumor immunity in conventional proton therapy.

Lorea IturriAnnaïg BerthoCharlotte LamiraultElise BrisebardMarjorie JuchauxCristèle GilbertJulie EspenonCatherine SébriéLaurène JourdainLudovic de MarziFrédéric PouzouletJane MuretPierre VerrelleYolanda Prezado

Published in: Communications medicine (2023)

These results demonstrate the need to further optimize anesthesia protocols used in radiotherapy with the goal of preserving normal tissues and achieving tumor control, specifically in combination with immunotherapy agents.

Keyphrases

early stage
gene expression
radiation therapy
locally advanced
radiation induced
squamous cell carcinoma