Comparison of IL-2-antibody to IL-2-Fc with or without stereotactic radiation therapy in CEA immunocompetent mice with CEA positive tumors.
Lindsay WilliamsLin LiPaul J YazakiPatty WongTeresa HongErasmus K PokuSusanta HuiHemendra GhimireJohn E ShivelyMaciej KujawskiPublished in: Cancer medicine (2024)
IL-2-Fc had comparable antitumor efficacy to CEA-targeted M5A-IL-2 ICK, while both fusion proteins induced immune memory when combined with SRT. Differences in the therapeutic mechanisms of both agents were observed.