Ultrathin Cell-Membrane-Mimic Phosphorylcholine Polymer Film Coating Enables Large Improvements for In Vivo Electrochemical Detection.
Xiaomeng LiuTongfang XiaoFei WuMo-Yuan ShenMeining ZhangHsiao-Hua YuLanqun MaoPublished in: Angewandte Chemie (International ed. in English) (2017)
Resisting biomolecule adsorption onto the surface of brain-implanted microelectrodes is a key issue for in vivo monitoring of neurochemicals. Herein, we demonstrate that an ultrathin cell-membrane-mimic film of ethylenedioxythiophene tailored with zwitterionic phosphorylcholine (EDOT-PC) electropolymerized onto the surface of a carbon fiber microelectrode (CFE) not only resists protein adsorption but also maintains the sensitivity and time response for in vivo monitoring of dopamine (DA). As a consequence, the as-prepared PEDOT-PC/CFEs could be used as a new reliable platform for tracking DA in vivo and would help understand the physiological and pathological functions of DA.
Keyphrases
- room temperature
- label free
- aqueous solution
- reduced graphene oxide
- gold nanoparticles
- high efficiency
- white matter
- metal organic framework
- deep brain stimulation
- high throughput
- ionic liquid
- resting state
- uric acid
- protein protein
- molecularly imprinted
- metabolic syndrome
- amino acid
- mass spectrometry
- real time pcr
- cerebral ischemia
- blood brain barrier
- single cell
- high resolution