UPR mt activation improves pathological alterations in cellular models of mitochondrial diseases.
Juan M Suárez-RiveroCarmen J Pastor-MaldonadoSuleva Povea-CabelloMónica Álvarez-CórdobaIrene Villalón-GarcíaMarta Talaverón-ReyAlejandra Suárez-CarrilloManuel Munuera-CabezaDiana Reche-LópezPaula Cilleros-HolgadoRocío Piñero-PerezJosé Antonio Sánchez-AlcázarPublished in: Orphanet journal of rare diseases (2022)
Overall, we provide compelling evidence to propose the activation of intrinsic cellular compensatory mechanisms as promising therapeutic strategy for mitochondrial diseases.
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