Brain perfusion changes in beta-thalassemia.
Renzo ManaraSara PonticorvoMarcella ContieriAntonietta CannaAndrea Gerardo RussoMaria Cristina FedeleMaria Chiara RoccoAdriana BorrielloSilvia ValeggiaMaria PennisiMarianna De AngelisDomenico RobertiMario CirilloFrancesco di SalleSilverio PerrottaFabrizio EspositoImmacolata TartaglionePublished in: Orphanet journal of rare diseases (2024)
Relative hyperperfusion of watershed territories represents a hemodynamic hallmark of beta-thalassemia anemia challenging previous hypotheses of brain injury in hereditary anemias. A careful management of anemia severity might be crucial for preventing structural white matter changes and subsequent long-term cognitive impairment.