Optimization of a Ligand Exchange Chromatography Method for the Enantioselective Separation of Levofloxacin and Its Chiral Impurity.

Fatima Zahra Abousalih Miloud El Karbane Fouad Echerfaoui Yassine Hameda Benchekroun Khalid Karrouchi Mohamed Azougagh Houda Bouchafra Mustapha Bouatia

Published in: Journal of AOAC International (2021)

The following method is accurate and robust to quantify and characterize the presence of levofloxacin impurity in raw material for pharmaceutical compounds.

Keyphrases

liquid chromatography
mass spectrometry
high speed
high resolution
tandem mass spectrometry
ionic liquid
high performance liquid chromatography
capillary electrophoresis