Moderate temperature reduction is sufficient for prevention of 5-fluorouracil-induced oral mucositis: an experimental in vivo study in rats.

Java Walladbegi Martin Johnsson Özgü Aydoğdu Mats Jontell Michael Winder

Published in: Cancer chemotherapy and pharmacology (2022)

Bolus i.v. injection with 5-FU in rats can be used to create a functional animal model for chemotherapy-induced OM. Further, moderate temperature reduction is sufficient to reduce the early events which may precede clinically established OM.

Keyphrases

chemotherapy induced
high intensity
high glucose
diabetic rats
radiation induced
drug induced