Efficacy of Tocilizumab in Patients Hospitalized with Covid-19.
John H StoneMatthew J FrigaultNaomi J Serling-BoydAna D FernandesLiam HarveyAndrea S FoulkesNora K HorickBrian C HealyRuta ShahAna Maria BensaciAnn E WoolleySarah NikiforowNina LinManish SagarHarry SchragerDavid S HuckinsMatthew AxelrodMichael D PincusJorge FleisherChana A SacksMichael DouganCrystal M NorthYuan-Di HalvorsenTara K ThurberZeina DagherAllison SchererRachel S WallworkArthur Y KimSara SchoenfeldPritha SenTomas G NeilanCory A PeruginoSebastian H UnizonyDeborah S CollierMark A MatzaJaneth M YinhKathryn A BowmanEric MeyerowitzAmna ZafarZsofia D DrobniMarcy B BolsterMinna KohlerKristin M D'SilvaJonathan DauMegan M LockwoodCaroline CubbisonBrittany N WeberMichael K Mansournull nullPublished in: The New England journal of medicine (2020)
Tocilizumab was not effective for preventing intubation or death in moderately ill hospitalized patients with Covid-19. Some benefit or harm cannot be ruled out, however, because the confidence intervals for efficacy comparisons were wide. (Funded by Genentech; ClinicalTrials.gov number, NCT04356937.).