Green Synthesis of CeO2 Nanoparticles from the Abelmoschus esculentus Extract: Evaluation of Antioxidant, Anticancer, Antibacterial, and Wound-Healing Activities.
Hafiz Ejaz AhmedYasir IqbalMuhammad Hammad AzizMuhammad AtifZahida BatoolAtif HanifNafeesah YaqubW A FarooqShafiq AhmadAmanullah FatehmullaHijaz AhmadPublished in: Molecules (Basel, Switzerland) (2021)
Metal oxide nanoparticles synthesized by the biological method represent the most recent research in nanotechnology. This study reports the rapid and ecofriendly approach for the synthesis of CeO2 nanoparticles mediated using the Abelmoschus esculentus extract. The medicinal plant extract acts as both a reducing and stabilizing agent. The characterization of CeO2 NPs was performed by scanning electron microscopy (SEM), X-ray diffraction (XRD), ultraviolet-visible spectroscopy (UV-Vis), and Fourier transform infrared spectroscopy (FTIR). The in vitro cytotoxicity of green synthesized CeO2 was assessed against cervical cancerous cells (HeLa). The exposure of CeO2 to HeLa cells at 10-125 µg/mL caused a loss in cellular viability against cervical cancerous cells in a dose-dependent manner. The antibacterial activity of the CeO2 was assessed against S. aureus and K. pneumonia. A significant improvement in wound-healing progression was observed when cerium oxide nanoparticles were incorporated into the chitosan hydrogel membrane as a wound dressing.
Keyphrases
- oxide nanoparticles
- wound healing
- cell cycle arrest
- induced apoptosis
- electron microscopy
- oxidative stress
- cell death
- high resolution
- anti inflammatory
- drug delivery
- endoplasmic reticulum stress
- pi k akt
- signaling pathway
- computed tomography
- cell proliferation
- silver nanoparticles
- extracorporeal membrane oxygenation
- mechanical ventilation
- drug induced